TABLE 2.

Clinicopathological variables and the expression of circ_0001946 in colorectal cancer patients.

Clinicopathological variable	N	Circ_0001946		P-value
		High expression	Low expression
Age
≤60 years	34	14 (41.2%)	20 (58.8%)	0.133
>60 years	30	18 (60.0%)	12 (40.0%)
Gender
Male	40	23 (57.5%)	17 (41.5%)	0.121
Female	24	9 (37.5%)	15 (62.5%)
Tumor size
≤6 cm	38	12 (31.6%)	26 (68.4%)	0.000
>6 cm	26	20 (76.9%)	6 (23.1%)
Histologic grade
High	47	19 (40.4%)	28 (59.6%)	0.011
Low	17	13 (76.5%)	4 (23.5%)
N stage
N0	36	12 (33.3%)	24 (66.7%)	0.002
N1-N2	28	20 (71.4%)	8 (28.6%)
Tnm stage
I-II	27	8 (29.6 %)	19 (70.3%)	0.005
III-IV	37	24 (64.9%)	13 (35.1%)
Cea level
Normal (0–5 μg/L)	34	9 (26.5%)	25 (73.5%)	0.000
Elevated (>5 μg/L)	30	23 (76.7%)	7 (23.3%)
CA19-9 level
Normal (0–37 U/ml)	31	19 (61.3%)	12 (38.7%)	0.080
Elevated (>37 U/ml)	33	13 (39.4%)	20 (60.6%)
Total	64	32 (50.0%)	32 (50.0%)

CEA, carcino-embryonic antigen; CA19-9, carbohydrate antigen 19-9.