FIGURE 3.

Host response plasma biomarker levels in patients with community-acquired pneumonia with the lowest and highest blood leukocyte TNF-α production following LPS stimulation. Patients were stratified into those with the lowest 25% blood leukocyte TNF-α production (low TNF-α producers, n = 20) and those with the highest 25% blood leukocyte TNF-α production (high TNF-α producers, n = 20) following LPS stimulation. Plasma biomarkers were measured upon hospital admission. Individual data points are displayed with the horizontal line depicting the median. Dotted lines indicate median values obtained in 42 healthy age- and sex-matched subjects. Values in patients were all significantly different from those in healthy control subjects. Asterisks indicate differences between patients with the lowest 25% and the highest 25% TNF-production following LPS stimulation (Benjamini-Hochberg corrected, *P < 0.05, **P < 0.01). CRP, C-reactive protein; MPO, myeloperoxidase; NGAL, neutrophil gelatinase-associated lipocalin; sE-Selectin, soluble E-selectin; sTREM-1, soluble triggering receptor expressed on myeloid cells 1; sVCAM-1, soluble vascular cell adhesion protein 1; TFF3, trefoil factor 3.