Table 2.

Associations between advanced presentation of retinoblastoma (IIRC grades D and E) and treatment, and demographic and socioeconomic factors (by ORs). n=189

	Advanced IIRC grade n=153/189 (81%)		Enucleation* n=134/189 (71%)		Adjuvant chemotherapy* n=68/134 (50%)
	Unadjusted OR	Adjusted OR	Unadjusted OR	Adjusted OR	Unadjusted OR	Adjusted OR
Gender
Female	1		1	1	1	1
Male	1.10	1.03 (0.46, 2.30)	1.01	1.04 (0.47, 2.30)	0.68	0.50 (0.22, 1.17)
Ethnicity
English/Scottish/Welsh	1	1	1	1	1	1
Indian/Pakistani/  Bangladeshi	2.86	3.13 (0.62, 16)	1.86	1.40 (0.36, 5.41)	0.75	0.75 (0.22, 2.59)
Black  Caribbean/African	0.82	0.59 (0.09, 3.72)	0.41	0.16 (0.02, 1.18)	0.28	0.35 (0.03, 4.20)
Mixed/other white or other	2.05	3.92 (0.77, 20)	1.34	0.93 (0.23, 3.76)	0.37	0.37 (0.09, 1.56)
IMD score (quintiles)
1 (most deprived)	1	1	1	1	1	1
2	0.57	0.61 (0.17, 2.15)	1.19	1.90 (0.59, 6.17)	1.13	0.94 (0.28, 3.14)
3	0.39	0.35 (0.09, 1.37)	1.11	2.55 (0.63, 10)	1.22	1.03 (0.25, 4.28)
4	0.82	0.79 (0.19, 3.39)	1.59	1.99 (0.54, 7.37)	0.92	0.55 (0.15, 2.04)
5 (least deprived)	0.55	0.57 (0.16, 2.07)	0.99	1.19 (0.36, 3.94)	0.81	0.66 (0.20, 2.25)
Age at diagnosis
<1 year	1	1	1	1	1	1
1 to <2 years	1.16	1.58 (0.59, 4.25)	1.62	1.39 (0.52, 3.74)	0.52	0.66 (0.19, 2.25)
2 to <3 years	3.53	6.24 (1.50, 26)	5.12	3.58 (0.96, 13)	0.29	0.66 (0.19, 2.30)
3 to 12 years	4.5	9.57 (2.34, 39)	6.22	4.30 (1.06, 17)	0.41	1.01 (0.31, 3.27)
Laterality
Unilateral	1	1	1	1	1	1
Bilateral	1.46	3.24 (1.23, 8.57)	0.52	0.48 (0.19, 1.20)	15	16 (4.8, 56)

Models adjusted for all factors in the table.

Blod values are statistically significant as 95% confidence interval of odds ratio does not include 1.

*Additional adjustment for IIRC groups.

IIRC, International Intraocular Retinoblastoma Classification; IMD, Index of Multiple Deprivation.