Table 2.

Multivariate Cox regression analysis showing the correlation of IDO expression before and after treatment with PFS and OS

Multivariate analysis (N=60)
PFS				OS
Variable	HR*	95% CI†	P value	Variable	HR*	95% CI†	P value
IDO1 (before treatment)				IDO1 (after treatment)
Negative	1.00			Negative	1.00
Positive	0.19	0.03 to 0.46	0.017	Positive	3.27	1.03 to 2.05	0.008
Smoke				Smoke
Light/never	1.00			Light/Never	1.00
Heavy	0.60	0.09 to 3.35	0.34	Heavy	0.66	0.17 to 1.91	0.38
Ethanol				EtOH
Social/no	1.00			Social/no	1.00
Heavy	3.26	0.58 to 3.78	0.071	Heavy	2.14	0.57 to 8.67	0.16
TNM stage‡				TNM stage
I–III	1.00			I–III	1.00
IV	2.33	0.30 to 9.45	0.15	IV	2.12	0.28 to 1.42	0.18
Sex				Sex
Male	1.00			Male	1.00
Female	0.80	0.27 to 2.41	0.80	Female	0.77	0.23 to 1.63	0.62

Bold values indicate statistical significance.

*HR estimated from Cox proportional hazard regression model.

†CI of the estimated HR. Results are based on 1000 bootstrap samples and obtained after the bias corrected and accelerated approach.

‡TNM staging system.

OS, overall survival; PFS, progression-free survival.