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The metabolism of arachidonic acid to EETs and its physiological function. Arachidonic acid through CYP epoxygenases is metabolite to EETs or through CYP hydroxylases to HETEs. EETs that can have local effects or endocrine effects improve kidney and endothelial function, attenuate inflammation and oxidative stress. On the other hand, HETEs promote hypertension inflammation and ROS production. EET, epoxyeicosatrienoic acid; HETE, hydroxyeicosatrienoic acid.
