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. 2020 May 5;37(10):1221–1232. doi: 10.1089/neu.2019.6742

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© Zhaoyu Wang et al., 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 4. — Symptom-associated DNA methylation analyses. (A) Differentially methylated genes associated with ringing in the ear/tinnitus in high relative to low blast-exposed groups, denoting genes implicated in auditory functioning by an asterisk (*). (B) Of note, KCNE1 and CYP2E1 genes follow the expected anticorrelated pattern of increase in DNA methylation with decrease in gene expression. CYP2E1, cytochrome P450 family 2 subfamily E member 1; DUSP12, dual specificity phosphatase 12; GPR148, G-protein-coupled receptor 148; KCNE1, potassium voltage-gated channel subfamily E member 1; LogFC, log fold-change; PGLYRP1, peptidoglycan recognition protein 1; PLXNB2, plexin B2; RGS14, regulator of G-protein signaling 14. Color image is available online.