Table 3.
Added Variance in A/D Outcome Association at 6 Months with Cerebrovascular Reactivity Monitoring Over IMPACT Core Models
| CORE (n = 193) | Δ Nagelkerke's pseudo-R2 |
|
|---|---|---|
| CORE | ||
| + % time PRx >0 | 0.128 | |
| + % time PRx >+0.25 | 0.176 | |
| + % time PRx >+0.35 | 0.193 | |
| CORE (n = 193) | Δ Nagelkerke's pseudo-R2 |
|
|---|---|---|
| CORE + mean ICP | ||
| + mean ICP |
+ % time PRx >0 |
0.075 |
| + % time PRx >+0.25 |
0.104 |
|
| + % time PRx >+0.35 |
0.115 |
|
| CORE + % time ICP >20 mm Hg | ||
| + % time ICP >20 mm Hg |
+ % time PRx >0 |
NS |
| + % time PRx >+0.25 |
0.077 |
|
| + % time PRx >+0.35 |
0.086 |
|
| CORE + % time ICP >22 mm Hg | ||
| + % time ICP >22 mm Hg | + % time PRx >0 |
NS |
| + % time PRx >+0.25 |
0.076 |
|
| + % time PRx >+0.35 | 0.086 | |
CORE model consisted of age, admission Glasgow Coma Scale motor score, and pupil response (normal bilaterally, unilateral unreactive, or bilaterally unreactive). CT variables consisted of admission Marshall CT grade, presence of traumatic subarachnoid hemorrhage, and presence of extradural hematoma. All numbers reported for Nagelkerke's pseudo-R2 are statistically significant (i.e., p < 0.05) increases in accounted variance in outcome association over the CORE or CORE + ICP models.
A/D, alive/dead dichotomized outcome; CPP, cerebral perfusion pressure; CT, computed tomography; ICP, intracranial pressure; IMPACT, International Mission for Prognosis and Analysis of Clinical Trials; MAP, mean arterial pressure; NS, non-significant; PRx, pressure reactivity index (correlation between ICP and MAP).