Table 2.
IgG Transport Across Sclera+Conjunctiva and Sclera Alone Using 20 Min Anodal Iontophoresis with IgG in Phosphate-Buffered Saline Versus New Electroosmosis Formulation (Low Ionic Strength, IgG Concentration = 25 mg/mL), n = 3
Sclera |
Conjunctiva+sclera |
||||||
---|---|---|---|---|---|---|---|
2 mA PBS | 2 mA new formulation | Passive PBS | 2 mA PBS | 4 mA PBS | 2 mA new formulation | 4 mA new formulation | |
Permeability (P) × 105 cm/s | 4.8 ± 1.8 | 16.9 ± 5.5 | 0.013 ± 0.007 | 3.1 ± 1.4 | 8.7 ± 4.1 | 8.3 ± 0.6 | 13.3 ± 3.2 |
Amount delivered (μg) | 288 ± 108 | 1,020 ± 300 | 0.78 ± 0.42 | 234 ± 114 | 522 ± 246 | 498 ± 36 | 780 ± 180 |
IgG, immunoglobulin G; PBS, phosphate-buffered saline.