Table 5.
Eye Tissue Distributions of IgG After 20 Min Anodal Iontophoresis at Two Different Current Densities: 1.86 and 3.6 mA/cm2
| Tissue (n = 6) | 3.6 mA/cm2 |
1.86 mA/cm2 |
||
|---|---|---|---|---|
| Amount of IgG (μg) | Conc. [IgG (μg)/g tissue] | Amount of IgG (μg) | Conc. [IgG (μg)/g tissue] | |
| Cornea | 112.5 ± 36.6 | 1470.2 ± 478.4 | 46.1 ± 12.1 | 602.1 ± 158.4 |
| Aqueous humor | 1.8 ± 0.2 | 6.3 ± 0.8 | 1.9 ± 1.1 | 6.9 ± 3.9 |
| Lens | 1.9 ± 1.4 | 4.6 ± 3.5 | 0.8 ± 0.6 | 2.1 ± 1.6 |
| Vitreous | 7.2 ± 2.9 | 4.9 ± 2.0 | 2.6 ± 1.3 | 1.8 ± 0.9 |
| Retina/choroid | 42.1 ± 38.8 | 268.6 ± 247.5 | 7.5 ± 7.4 | 48.1 ± 47.0 |
| Sclera | 186.9 ± 75.4 | 539.1 ± 217.5 | 131.4 ± 37.3 | 378.9 ± 107.5 |
| Conjunctiva | 374.6 ± 113.9 | 545.3 ± 165.8 | 247.6 ± 42.5 | 360.4 ± 61.9 |
| Total | 727.1 ± 37.7 | 438.0 ± 63.3 | ||
The higher current density (3.6 mA/cm2), the applicator was replaced at 10 min to maintain neutral pH in the applicator.
Conc., concentration.