Table 3.
Diagnostic performance of the urine test for the diagnosis of primary urothelial carcinoma.
| Biomarker | Primary UC | %sensitivity (95% CI) | %specificity (95% CI) | %accuracy (95% CI) | %PPV (95% CI) | %NPV (95% CI) | |
|---|---|---|---|---|---|---|---|
| No. of patients | |||||||
| Yes | No | ||||||
| n = 1228∗ | |||||||
| NMP22 | 37.9 | 95.8 | 91.0 | 45.3 | 94.4 | ||
| Positive | 39 | 47 | (28.5-48.0) | (94.5-96.9) | (89.4-92.6) | (34.6-56.5) | (92.9-95.7) |
| Negative | 64 | 1078 | |||||
| n = 90# | |||||||
| NMP22 | 41.7 | 83.3 | 61.1 | 74.1 | 55.6 | ||
| Positive | 20 | 7 | (27.6-56.8) | (68.6-93.0) | (50.8-71.4) | (56.4-91.7) | (42.9-68.2) |
| Negative | 28 | 35 | |||||
| Cytology | 54.2 | 97.6 | 74.4 | 96.3 | 65.1 | ||
| Positive | 26 | 1 | (39.2-68.6) | (87.4-99.9) | (65.3-83.6) | (80.6-99.9) | (52.0-76.7) |
| Negative | 22 | 41 | |||||
| Combination | 64.6 | 83.3 | 73.3 | 81.6 | 67.3 | ||
| Positive | 31 | 7 | (49.5-77.8) | (68.6-93.0) | (64.0-82.6) | (65.4-92.4) | (52.7-79.8) |
| Negative | 17 | 35 | |||||
Note: ∗patients performed the NMP22 BladderChek tests; #patients performed the NMP22 BladderChek tests and urine cytology tests; UC, urothelial carcinoma; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.