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Tetrandrine treatment improved cardiac function in DOX-treated mice. (a) Heart rate in the indicated groups (n = 8). (b–d) Alterations in +dP/dt, LVSP, and EF in mice (n = 8). (e, f) Cardiac output and stroke work of mice (n = 8). (g–i) LVEDP and Tau values (n = 8). (j–l) PRSW, dP/dt-EDV, and Emax of the mice (n = 8). ∗P < 0.05 compared with the saline group. #P < 0.05 compared with mice after DOX injection.
