Figure 3.

Tetrandrine treatment reduced oxidative stress in DOX-treated mice. (a) The mRNA levels of inflammatory factors in the hearts (n = 6). (b) NF-κB activation (n = 6). (c–e) The levels of 4-HNE, hydrogen peroxide, and MDA in the hearts (n = 6). (f, g) Gpx, total SOD, and MnSOD activities in the hearts (n = 6). (h) Reduced/oxidized GSH (n = 6). (i) Nuclear Nrf2 protein expression (n = 6). (j) Gene expression of target genes (n = 6). ^∗P < 0.05 compared with the saline group. ^#P < 0.05 compared with mice after DOX injection.