Figure 4.
HOTAIR bound to miR-217 and regulated miR-217 expression. (a). Sequence alignment of the predicted HOTAIR binding sites within the mir-217 5'UTR by starbase. (b). Real-time RT-PCR analysis of miR-217 in four HCC cell lines transfected with si-HOTAIR. ∗∗∗p < 0.001. (c). Real-time RT-PCR analysis of miR-217 in four HCC cell lines transfected with an miR-217 mimic, inhibitor, or NC.∗∗p < 0.01, ∗∗∗p < 0.001. (d). CCK8 analysis of sorafenib chemosensitivity in four HCC cell lines transfected with an miR-217 mimic, inhibitor, or NC. ∗p < 0.05, ∗∗∗p < 0.001.