Table 3.
Genotype and allele frequencies of IL-1β-511C/T, IL-6-174G/C, TNF-α-1031T/C, and TGFβ1-509T/C gene polymorphisms in RSA patients with or without PCOS and controls.
| Gene polymorphism | RSA with PCOS | RSA without PCOS | Control | RSA with PCOS vs. control | RSA without PCOS vs. control | RSA with PCOS vs. RSA without PCOS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | OR (95% CI) | χ 2 | p | OR (95% CI) | χ 2 | p | OR (95% CI) | χ 2 | p | ||
| IL-1β-511C/T (rs16944) | CC | 26 (37.7) | 33 (47.9) | 47 (33.8) | 0.73 (0.35-1.47) | 0.79 | 0.374 | 1.51 (3.43-0.66) | 0.98 | 0.323 | 2.08 (0.85-5.09) | 2.64 | 0.104 |
| CT | 27 (39.1) | 28 (39.4) | 67 (48.2) | 0.73 (0.37-1.40) | 0.90 | 0.342 | 0.58 (0.31-1.07) | 2.99 | 0.083 | 0.79 (0.38-1.65) | 0.38 | 0.536 | |
| TT | 16 (23.2) | 9 (12.7) | 25 (18.0) | 0.85 (0.46-1.54) | 0.30 | 0.582 | 0.56 (0.31-0.99) | 3.93 | 0.047∗ | 0.66 (0.33-1.29) | 1.49 | 0.222 | |
| Allele | C | 79 (57.3) | 96 (67.6) | 161 (57.9) | 0.97 (0.64-1.47) | 0.02 | 0.896 | 1.51 (0.99-2.31) | 3.72 | 0.053 | 1.56 (0.95-2.53) | 3.20 | 0.073 |
| T | 59 (42.7) | 46 (32.4) | 117 (42.1) | 1.03 (0.68-1.55) | 0.66 (0.43-1.00) | 0.64 (0.39-1.04) | |||||||
| n = 69 | n = 70 | n = 139 | |||||||||||
|
| |||||||||||||
| IL-6-174G/C (rs1800795) | GG | 42 (60.0) | 43 (62.0) | 88 (65.2) | 0.28 (0.07-0.97) | 4.50 | 0.033∗ | 0.69 (0.15-3.18) | 0.23 | 0.634 | 2.52 (0.62-10.16) | 1.78 | 0.181 |
| GC | 21 (30.0) | 24 (33.8) | 43 (31.8) | 0.28 (0.07-1.06) | 3.81 | 0.050∗ | 0.74 (0.15-3.60) | 0.14 | 0.712 | 2.67 (0.61-11.64) | 1.78 | 0.181 | |
| CC | 7 (10.0) | 3 (4.2) | 4 (3.0) | 1.25 (0.68-2.26) | 0.53 | 0.464 | 1.15 (0.63-2.08) | 0.21 | 0.647 | 0.92 (0.46-1.81) | 0.06 | 0.810 | |
| Allele | G | 105 (75.0) | 112 (78.9) | 219 (81.1) | 0.70 (0.42-1.13) | 2.08 | 0.149 | 0.87 (0.52-1.44) | 0.30 | 0.587 | 0.87 (0.52-1.44) | 0.60 | 0.440 |
| C | 35 (25.0) | 30 (21.1) | 51 (18.9) | 1.43 (0.87-2.33) | 1.15 (0.69-1.90) | 0.80 (0.46-1.40) | |||||||
| n = 70 | n = 70 | n = 135 | |||||||||||
|
| |||||||||||||
| TNF-α-1031T/C (rs1799964) | TT | 50 (73.5) | 44 (62.5) | 82 (59.9) | 4.71 (0.58-37.97) | 2.55 | 0.110 | 1.62 (0.42-6.17) | 0.50 | 0.478 | 0.34 (0.03-3.38) | 0.92 | 0.338 |
| TC | 17 (25.0) | 23 (33.3) | 46 (33.6) | 3.33 (0.39-28.25) | 1.34 | 0.247 | 1.57 (0.38-6.32) | 0.40 | 0.527 | 0.47 (0.04-4.91) | 0.41 | 0.521 | |
| CC | 1 (1.5) | 3 (4.2) | 9 (6.5) | 0.54 (0.28-1.01) | 3.71 | 0.054 | 0.90 (0.49-1.60) | 0.14 | 0.709 | 1.67 (0.81-3.42) | 1.95 | 0.162 | |
| Allele | T | 117 (86.0) | 114 (79.2) | 210 (76.6) | 1.88 (1.07-3.28) | 4.96 | 0.025∗ | 1.16 (0.71-1.89) | 0.35 | 0.556 | 0.62 (0.32-1.15) | 2.28 | 0.130 |
| C | 19 (14.0) | 30 (20.8) | 64 (23.4) | 0.53 (0.30-0.93) | 0.86 (0.52-1.40) | 1.62 (0.86-3.04) | |||||||
| n = 68 | n = 70 | n = 137 | |||||||||||
|
| |||||||||||||
| TGFβ1-509T/C (rs1800469) | TT | 29 (42.0) | 30 (42.9) | 60 (44.5) | 1.17 (0.48-2.85) | 0.12 | 0.724 | 2.54 (0.82-7.81) | 2.79 | 0.094 | 2.16 (0.62-7.55) | 1.52 | 0.217 |
| TC | 32 (46.4) | 36 (51.4) | 57 (42.2) | 1.26 (0.49-3.22) | 0.24 | 0.625 | 2.84 (0.89-9.07) | 3.30 | 0.069 | 2.25 (0.61-8.18) | 1.57 | 0.210 | |
| CC | 8 (11.6) | 4 (5.7) | 18 (13.3) | 1.10 (0.61-1.98) | 0.11 | 0.742 | 1.07 (0.59-1.91) | 0.05 | 0.828 | 0.97 (0.49-1.89) | 0.01 | 0.921 | |
| Allele | T | 90 (65.2) | 96 (68.6) | 177 (65.6) | 0.99 (0.64-1.51) | 0.00 | 0.945 | 1.15 (0.74-1.77) | 0.38 | 0.539 | 1.16 (0.70-1.91) | 0.35 | 0.552 |
| C | 48 (34.8) | 44 (31.4) | 93 (34.4) | 1.02 (0.66-1.56) | 0.87 (0.56-1.34) | 0.86 (0.52-1.41) | |||||||
| n = 69 | n = 70 | n = 135 | |||||||||||
OR: odds ratio; CI: confidence interval; ∗significant difference.