Figure 2.

Comparison of the total volume of distribution (V_T) and K₁ values determined using 1TCM and 2TCM based on IDIF. Correlation of the V_{T (IDIF)} (a) and K_{1 (IDIF)} (b) values calculated using 1TCM and 2TCM based on 90-min acquisition. The solid line represents the linear regression, while the dashed line depicts the identity line. (c and d) Bland–Altman plot to compare 1TCM and 2TCM in estimation of V_{T (IDIF)} and K_{1 (IDIF)}, respectively. Dashed line represents the bias between the two approaches, while the dotted lines denote the 95% limits of agreement. n = 10. Each symbol represents a different region. 1TCM: one-tissue compartmental model; 2TCM: two-tissue compartmental model; V_{T (IDIF)}: total volume of distribution using IDIF.