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. 2019 Jul 15;40(6):1351–1362. doi: 10.1177/0271678X19864081

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Population-based plasma metabolism of [¹¹C]UCB-J in mice. (a) Population-based curve of intact [¹¹C]UCB-J in plasma of healthy wild-type (WT) and diseased (model of Huntington's disease, HD) mice. n = 3 per genotype at each time point. (b) Sigmoid fitting curve of the intact [¹¹C]UCB-J in WT mice. (c) Comparison of representative image-derived input functions (IDIF) corrected and uncorrected for the population-based sigmoid fitting of intact [¹¹C]UCB-J. Scatter plots between V_{T (IDIF)} (Logan) corrected and uncorrected for the population-based sigmoid fitting of intact [¹¹C]UCB-J based on a total of five WT mice (d) and correlations for each individual WT mouse (e) in different brain regions. Individual animals presented different regression line equations.