Table 2.
In vivo kinetic parameters of [11C]UCB-J determined using 1TCM, 2TCM, and Logan plot based on 90-min acquisition in the mouse brain.
| 1TCM |
2TCM |
Logan plot |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
K1(IDIF)
(mL/cm3/min) |
k2 (IDIF) (per
min) |
VT (IDIF)
(mL/cm3) |
VT (IDIF)
(mL/cm3) |
VT (IDIF)
(mL/cm3) |
||||||
| Region | Mean ± SD | COV (%) | Mean ± SD | COV (%) | Mean ± SD | COV (%) | Mean ± SD | COV (%) | Mean ± SD | COV (%) |
| Striatum | 1.52 ± 0.21 | 13.67 | 0.27 ± 0.029 | 10.85 | 5.63 ± 0.43 | 7.67 | 5.66 ± 0.44 | 7.91 | 5.17 ± 0.34 | 6.69 |
| Thalamus | 1.99 ± 0.33 | 16.91 | 0.28 ± 0.037 | 13.12 | 6.96 ± 0.55 | 7.94 | 6.98 ± 0.54 | 7.79 | 6.28 ± 0.43 | 6.85 |
| Motor Cortex | 1.59 ± 0.28 | 17.78 | 0.26 ± 0.03 | 14.13 | 6.00 ± 0.47 | 7.91 | 6.01 ± 0.48 | 7.94 | 5.46 ± 0.38 | 6.97 |
| Hippocampus | 1.65 ± 0.24 | 14.83 | 0.26 ± 0.03 | 11.35 | 6.28 ± 0.48 | 7.61 | 6.30 ± 0.48 | 7.56 | 5.82 ± 0.37 | 6.45 |
| Cerebellum | 1.40 ± 0.27 | 19.62 | 0.32 ± 0.05 | 17.35 | 4.41 ± 0.35 | 8.03 | 4.42 ± 0.36 | 8.07 | 3.82 ± 0.27 | 7.05 |
Note: The microparameters for 2TCM are not reported due to the low reliability (relative standard errors were above 20%).
1TCM: one-tissue compartmental model; 2TCM: two-tissue compartmental model; VT (IDIF): total volume of distribution using IDIF; COV: coefficient of variation.