Fig. 1.

A. Reconstructed μCT skeletal images from male OI and WT mice with and without an Lrp5 HBM allele, and with TGFβ neutralizing antibody or control antibody. Midshaft femur cortical thickness only increases with the Lrp5 HBM allele, whereas femoral and vertebral bone mass increase with either the Lrp5 HBM allele or TGFβ neutralizing antibody. B–D. Bar graphs depicting mean (± 1 SE) total body BMD by DXA and μCT measured femoral and vertebral BV/TV in combined male and female OI and WT mice with and without an Lrp5 HBM allele, and TGFβ neutralizing antibody or control antibody. Note that combining the Lrp5 HBM allele with TGFβ neutralizing antibody further increases femoral and vertebral trabecular BV/TV.