Table 2.
Prognostic variables, survivals, and their hazard ratios (HRs) of the 73 CRC patients
| Prognostic variables | Survival differences | Cox’s proportional hazards regression | ||||
|---|---|---|---|---|---|---|
| Survival, months | Log-rank | Univariate | Multivariate | |||
| Mean (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| Gender | 0.361 | |||||
| Female (n = 30) | 81.3 (61.3–101.2) | 1.000 | 1.000 | |||
| Male (n = 43) | 97.5 (81.2–113.9) | 0.715 (0.347–1.475) | 0.364 | 2.354 (0699–7.929) | 0.167 | |
| Age (years) | 0.592 | |||||
| ≤65 (n = 44) | 87.1 (70.9–103.2) | 1.003 (0.973–1.035)* | 0.649 | 1.039 (0.981–1.102)* | 0.193 | |
| >65 (n = 29) | 94.8 (74.6–115.1) | - | - | |||
| Maximal tumor diameter (cm) | 0.132 | |||||
| ≤5 (n = 44) | 94.2 (79.4–108.9) | 1.000 | ||||
| >5 m (n = 29) | 78.4 (57.4–99.5) | 1.726 (0.841–3.544) | 0.137 | |||
| T-status | 0.074 | |||||
| T1/T2 (n = 13) | 114.5 (95.8–133.2) | 1.000 | 1.000 | |||
| T3 (n = 56) | 87.9 (73.0–102.9) | 3.221 (0.762–13.612) | 0.112 | 0.431 (0.067–2.768) | 0.375 | |
| T4 (n = 5) | 51.4 (9.8–92.9) | 7.100 (1.179–42.754) | 0.032 | 0.316 (0.023–4.304) | 0.387 | |
| N-status | < 0.001 | |||||
| N0 (n = 31) | 127.1 (115.9–138.3) | 1.000 | 1.000 | |||
| N1 (n = 17) | 86.0 (62.3–109.6) | 5.267 (1.396–19.863) | 0.014 | 5.749 (0.959–34.480) | 0.056 | |
| N2 (n = 25) | 50.9 (31.0–70.8) | 12.896 (3.793–43.843) | < 0.001 | 17.677 (2.048–152.605) | 0.009 | |
| M-status | < 0.001 | |||||
| M0 (n = 67) | 98.5 (85.6–111.4) | 1.000 | 1.000 | |||
| M1 (n = 6) | 16.2 (3.7–28.7) | 7.708 (2.957–20.095) | < 0.001 | 7.517 (1.626–34.756) | 0.010 | |
| Stage | < 0.001 | |||||
| I (n = 12) | 113.6 (93.3–133.9) | 1.000 | ||||
| II (n = 19) | 132.2 (122.2–142.2) | 0.284 (0.026–3.128) | 0.303 | |||
| III (n = 36) | 74.6 (56.9–92.3) | 4.100 (0.959–17.521) | 0.057 | |||
| IV (n = 6) | 16.2 (3.7–28.7) | 18.011 (3.476–93.338) | 0.001 | |||
| Lymphatic vessel invasion | 0.001 | |||||
| No (n = 42) | 100.1 (86.7–113.6) | 1.000 | 1.000 | |||
| Yes (n = 22) | 52.8 (31.9–73.6) | 3.276 (1.509–7.114) | 0.003 | 0.832 (0.226–3.060) | 0.782 | |
| Venous vessel invasion | 0.001 | |||||
| No (n = 52) | 94.4 (81.1–107.7) | 1.000 | 1.000 | |||
| Yes (n = 11) | 39.2 (16.8–61.6) | 3.782 (1.590–8.993) | 0.003 | 2.828 (0.398–20.120) | 0.299 | |
| Perineural invasion | 0.037 | |||||
| No (n = 53) | 90.5 (76.7–104.2) | 1.000 | 1.000 | |||
| Yes (n = 4) | 33.7 (0.0–72.0) | 3.402 (0.996–11.625) | 0.051 | 1.702 (0.192–15.084) | 0.633 | |
| Histological grade | 0.022 | |||||
| Low grade (n = 51) | 94.9 (81.0–108.8) | 1.000 | 1.000 | |||
| Intermediate/high grade (n = 22) | 71.2 (48.8–93.6) | 2.266 (1.103–4.656) | 0.026 | 2.332 (0.814–6.680) | 0.115 | |
| Tumor configuration | 0.104 | |||||
| Exophytic (n = 25) | 104.1 (87.9–120.3) | 1.000 | ||||
| Ulcerative (n = 48) | 82.7 (66.1–99.3) | 1.991 (0.853–4.646) | 0.111 | |||
| No. of TDNLs | 0.448 | |||||
| ≤ 10 (25 percentile, n = 20) | 88.1 (66.0–110.3) | 1.783 (0.548–5.803) | 0.337 | |||
| 10–29 (25–75 percentile, n = 37) | 85.1 (66.4–103.7) | 1.998 (0.671–5.950) | 0.214 | |||
| > 29 (75 percentile, n = 16) | 97.7 (74.8–121.1) | 1.000 | ||||
| No. of NDLNs | 0.071 | |||||
| ≤ 9 (25 percentile, n = 22) | 69.8 (48.1–91.5) | 2.661 (0.956–7.405) | 0.061 | 0.727 (0.153–3.448) | 0.688 | |
| 9–27 (25–75 percentile, n = 33) | 98.3 (79.0–117.5) | 1.300 (0.451–3.752) | 0.627 | 0.406 (0.074–2.223) | 0.299 | |
| > 27 (75 percentile, n = 18) | 97.4 (76.5–118.2) | 1.000 | 1.000 | |||
CRC colorectal cancer, No. number, TDLNs total dissected lymph nodes, NDLNs negative dissected lymph nodes, SD standard deviation, CI confidence interval
*Considered as a continuous variable