Table 4:
Percent Mediation of Allostatic Load on the Association of Depressive Symptoms with Incident Coronary Heart Disease in the Jackson Heart Study
| Overall (n = 2,670) | Women (n = 1,749) | Men (n = 921) | ||||
|---|---|---|---|---|---|---|
| % Mediated | p | % Mediated | p | % Mediated | p | |
| Metabolic AL z-score | 5.79 | 0.044 | 6.18 | 0.016 | −2.16 | 0.840 |
| Cardiovascular AL z-score | 1.78 | 0.254 | 1.54 | 0.500 | −0.19 | 0.920 |
| Immune AL z-score | 2.29 | 0.256 | 0.17 | 0.934 | 1.66 | 0.810 |
| Neuroendocrine AL z-score | −0.57 | 0.744 | −0.03 | 0.952 | −2.95 | 0.780 |
| AL Meta-factor z-score | 7.55 | 0.016 | 4.94 | 0.116 | −0.20 | 0.990 |
Note: p values of <0.05 considered statistically significant; Models adjusted for age, sex, education, occupation, smoking and physical activity; AL = allostatic load