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Trans-neuronal machinery as a possible mechanism of CoV neuroinvasion. In the trans-neuronal route, the virus infects a peripheral neuron and by retrograde transport and infects another neuron via synapse. The virus is released by the process of exocytosis in the presynaptic terminal. It then binds to ACE-2 receptors on the postsynaptic neuron and taken up via receptor-mediated endocytosis. ACE-2, angiotensin-converting enzyme 2
