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(A) Lkb1 controls mitochondrial homeostasis and axonal ATP production, through Efhd1 and additional pathways that are required for axonal morphogenesis. (B) Complete ablation of Efhd1 causes reduction in the axonal ATP levels and mitochondrial abnormalities. This results in the activation of AMPK and Ulk and increased autophagic flux, which is correlated with reduced axonal morphogenesis.
