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. 2020 Jan 17;30(6):3827–3837. doi: 10.1093/cercor/bhz345

Figure 3.

Figure 3

Functional connectivity analysis (PPI) using three thalamic seeds driven by increased familiarity strength (positive PPI; a and b) or decreased familiarity strength (negative PPI; c). Clusters of significant activation are displayed at a voxel-wise P < 0.001 and are significant at cluster-wise FWE P < 0.05 determined with nonparametric permutation testing (with 5000 permutations; all ts > 3.75). (d) Schematic summary of intrathalamic and thalamic-MTL functional connectivity patterns supporting familiarity memory. Material-specificity in the connectivity profiles is informed by the univariate and PPI analyses and correlational analysis reported in Suppl. Results and Suppl. Figure 1. MDt-PRC connectivity supports familiarity for objects and faces, while MDt-PHC connectivity supports familiarity for scenes. Within the thalamus, material-specific regions (VLt for faces and VPt for scenes) directly communicated with the MDt. Abbreviations: PHC = parahippocampal cortex; PRC = perirhinal cortex; HC = hippocampus; AMG = amygdala; MDt = mediodorsal thalamus; VLt = ventral lateral thalamus; VPt = ventral posterior thalamus (including pulvinar).