Table 2.
Hippocampal volumes and LCT measurements in MCI patients and healthy controls.
| Healthy (n=79) | MCI (n=79) | P value | |
|---|---|---|---|
| Hippocampus | |||
| Total (mm3) | 7.73±0.61 | 6.41±0.52 | <0.001 |
| Right (mm3) | 3.85±0.36 | 3.29±0.21 | <0.001 |
| Left (mm3) | 3.82±0.33 | 3.26±0.22 | <0.001 |
| CSF | |||
| Pressure (mmHg) | 13.1± 2.2 | 13.6±2.5 | P=0.24 |
| Aβ1–42 (pg/mL) | 471.25±130.79 | 338.51± 122.05 | <0.001 |
| T-tau (pg/mL) | 64.09±18.21 | 93.18±25.01 | <0.001 |
| P-tau181P (pg/mL) | 25.49±12.06 | 36.64±15.23 | <0.001 |
| LCT (μm) | |||
| Superior | 230.81±15.92 | 209.25±15.80 | <0.001 |
| Central | 259.82±16.91 | 246.61±17.06 | <0.001 |
| Inferior | 238.06±18.25 | 221.62±17.21 | <0.001 |
| Average | 246.25±16.08 | 228.03±16.65 | <0.001 |
| LCD (μm) | 436.54±77.29 | 433.69±87.70 | 0.72 |
Data are presented as the mean±standard deviation unless otherwise specified. MCI – mild cognitive impairment; Aβ1–42 – amyloid β1–42; CSF – cerebrospinal fluid; LCD – lamina cribrosa depth; LCT – lamina cribrosa thickness.