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. Author manuscript; available in PMC: 2021 Apr 10.
Published in final edited form as: Circ Res. 2020 Mar 9;126(8):1024–1039. doi: 10.1161/CIRCRESAHA.119.315956

Figure 1. Characterization of TAZ-KO mice.

Figure 1.

A. Schematic of TAZ wild-type, floxed, and deleted alleles. B. PCR genotyping. C. Loss of TAZ protein in TAZ-KO. Capillary immunoblotting of cardiac tissue from TAZ-KO and wild-type mice. D. Survival of TAZ-KO mice. TAZ-KO (Δ/Y) mice were present at below the expected Mendalian ratio from birth. E. Survival curve for live born control and TAZ-KO mice. Shading, 95% confidence interval. F. Cardiac contraction evaluated by echocardiography at P1. FS, fractional shortening. G. Survival curve for live born mice, with TAZ-KO mice classified by body weight at P1. Shading, 95% confidence interval. Statistical significance between TAZ-KO groups is shown. H. Photograph of TAZ-KO and control littermates at P14. Bar = 1 cm. I. Cardiac MLCL/CL ratio at 2 months and 6 months, as measured by mass spectrometry. Statistical tests: E,G: Mantel-Cox; F,I: t-test.