Table 4.
Results of the histological examination of nodules.
| Time point | Treatment group(s)a | No. nodules | No. female worms | No. fertile | No. shedding oocytes | No. empty | No. dead | % fertile females | % worms fertile or shedding oocytes |
|---|---|---|---|---|---|---|---|---|---|
| D0 | A | 6 | 12 | 1 | 8 | 2 | 1 | 8.3 | 75.0 |
| B | 6 | 7 | 2 | 3 | 1 | 1 | 28.6 | 71.4 | |
| C | 5 | 5 | 3 | 2 | 0 | 0 | 60.0 | 100 | |
| A + B + C | 16 | 24 | 6 | 13 | 3 | 2 | 25.0 | 79.2 | |
| M6 | A | 7 | 6 | 0 | 5 | 1 | 0 | 0 | 83.3 |
| B | 5 | 5 | 0 | 5 | 0 | 0 | 0 | 100 | |
| C | 3 | 1 | 1 | 0 | 0 | 0 | 100 | 100 | |
| M12 | A | 8 | 8 | 0 | 3 | 5 | 0 | 0 | 37.5 |
| B | 7 | 5 | 0 | 2 | 3 | 0 | 0 | 40.0 | |
| C | 5 | 6 | 2 | 1 | 1 | 2 | 33.3 | 50.0 | |
| M6 | A + B | 12 | 11 | 0 | 10 | 1 | 0 | 0 | 90.9 |
| M12 | A + B | 15 | 13 | 0 | 5 | 8 | 0 | 0 | 38.5 |
| All naïve wormsb | 24 | 31 | 9 | 14 | 4 | 4 | 29.0 | 74.2 |
a
A = 500 mg IVM; B = 1000 mg IVM; C = control (vehicle only).
b
All worms (groups A, B, and C) collected at D0 and worms in group C collected at M6 and M12.