Table 1.

Inhibitory activities of compounds 1–25 against sEH.

Compounds	Inhibition of compounds against sEH
	50 μM (%)	IC50 (μM)
1	75.31 ± 2.42	7.15 ± 1.09
2	27.33 ± 2.81	>50
3	78.54 ± 1.86	14.8 ± 1.1
4	71.21 ± 1.56	5.94 ± 0.54
5	95.23 ± 1.24	3.40 ± 0.57
6	71.6 ± 2.12	14.6 ± 1.1
7	24.45 ± 1.03	>50
8	44.42 ± 1.43	>50
9	37.63 ± 0.86	>50
10	18.64 ± 0.45	>50
11	65.62 ± 1.65	36.3 ± 4.0
12	44.97 ± 0.95	>50
13	66.84 ± 2.09	22.1 ± 1.4
14	18.30 ± 0.35	>50
15	78.66 ± 2.19	9.57 ± 0.88
16	58.56 ± 1.31	21.2 ± 0.5
17	49.44 ± 1.15	>50
18	56.93 ± 1.26	31.5 ± 1.4
19	58.34 ± 1.31	22.2 ± 1.0
20	17.63 ± 0.56	>50
21	39.33 ± 0.92	>50
22	17.96 ± 0.69	>50
23	16.27 ± 0.72	>50
24	59.45 ± 1.53	14.6 ± 1.6
25	56.98 ± 1.86	21.4 ± 1.7
TPPUa	-b	53 nM

^aPositive control.

^bNo tested.