Table 3.

Interaction information of compounds 4 and 5 with sEH.

Compounds	Interaction amino acids	Hydrogen bonds	Lowest binding energy (kcal/mol)
4	Asp335, Trp336, Met339, Thr360, Ile363, Pro371, Ile375, Phe381,Tyr383, Gln384, Tyr466, Val498, Leu499, His524	Asp335, Tyr383, Tyr466	−36.45
5	Asp335, Trp336, Met339, Tyr343, Thr360, Ala365, Ile363, Pro371, Tyr383, Gln384, Met469, Tyr466, Trp473	Trp336, Tyr466	−40.52