Table II.

P values, AUC values, and optimal cutoffs in the evaluation, validation, and combined cohorts

Variable	Evaluation set						Validation set						Combined cohort
	At presentation			Maximal			At presentation			Maximal			At presentation			Maximal
	P value	AUC (CI)	Cutoff	P value	AUC (CI)	Cutoff	P value	AUC (CI)	Cutoff	P value	AUC (CI)	Cutoff	P value	AUC (CI)	Cutoff	P value	AUC (CI)	Cutoff
IL-6 level (pg/mL)	.000012	0.94 (0.86-1.00)	35	5.4 × 10–8	0.97 (0.93-1.00)	80	.000076	0.84 (0.73-0.95)	48.9	4.9×10–7	0.90 (0.81-0.98)	60	2.3 × 10–9	0.89 (0.81-0.96)	48.9	2.6 × 10–11	0.93 (0.88-0.98)	65
CRP level (mg/L)	.0031	0.79 (0.65-0.93)	32.5	.00027	0.86 (0.74-0.98)	97	.000032	0.86 (0.75-0.96)	32.5	.000097	0.83 (0.72-0.95)	97	1.9 × 10–7	0.83 (0.75-0.92)	32.5	7.0 × 10–8	0.85 (0.76-0.93)	97
PCT level (ng/mL)	.0043	0.74 (0.58-0.90)	0.05	.0084	0.74 (0.57-0.91)	0.25	.000073	0.81 (0.69-0.93)	0.05	.00015	0.80 (0.67-0.93)	0.25	8.7 × 10–7	0.78 (0.68-0.88)	0.05	4.2 × 10–6	0.78 (0.67-0.88)	0.25
LDH level (U/L)	.00062	0.83 (0.70-0.97)	320	.071	0.68 (0.50-0.86)	590	.00032	0.81 (0.67-0.95)	410	.0076	0.73 (0.60-0.89)	440	1.4 × 10–6	0.81 (0.72-0.91)	410	.0015	0.70 (0.59-0.82)	380.5
WBC level (G/L)	.0028	0.80 (0.66-0.93)	4920	.010	0.75 (0.58-0.93)	9860	.13	0.63 (0.45-0.81)	6190	.30	0.59 (0.41-0.77)	10510	.0024	0.69 (0.57-0.81)	6190	.015	0.66 (0.53-0.78)	9860
Creatinine level (mg/dL)	.00051	0.84 (0.72-0.96)	0.95	.00028	0.85 (0.74-0.97)	1.05	.0023	0.76 (0.63-0.89)	0.95	.026	0.69 (0.54-0.84)	1.05	5.2 × 10–6	0.79 (0.70-0.88)	0.95	.000070	0.75 (0.65-0.86)	1.05
Troponin level (ng/mL)	.0053	0.72 (0.56-0.88)	0.005	.0079	0.72 (0.55-0.90)	0.005	.0078	0.72 (0.57-0.87)	0.005	.020	0.69 (0.54-0.85)	0.005	.00010	0.73 (0.62-0.83)	0.005	.00027	0.72 (0.61-0.83)	0.005
Ferritin level (ng/mL)	.064	0.72 (0.52-0.91)	766	.12	0.68 (0.47-0.89)	530	.0026	0.76 (0.62-0.90)	1285	.010	0.72 (0.58-0.87)	1510	.00023	0.75 (0.64-0.86)	1285	.0024	0.71 (0.59-0.83)	1610

LDH, Lactate dehydrogenase; PCT, procalcitonin; WBC, white blood cell count.