Table E3.
Comparison of the evaluation and validation cohorts
| Variable | Cohort |
P value | |
|---|---|---|---|
| Evaluation (n = 40) | Validation (n = 49) | ||
| Baseline characteristics∗ | |||
| Median age, y (range) | 57 (19-81) | 64 (18-84) | .15 |
| Median respiratory rate, breaths/min (range) | 18 (14-40) | 18 (11-40) | .76 |
| Median heart rate (beats/min) | 81 (54-112) | 90 (64-130) | .017 |
| Median BMI, kg/m2 (range) | 25.9 (19.0-45.7) | 27.5 (18.1-36.2) | .18 |
| Male sex, n (%) | 29 (72) | 33 (67) | .77 |
| Any comorbidity, n (%) | 32 (82) | 38 (79) | .95 |
| Hypertension, n (%) | 19 (50) | 26 (54) | .87 |
| Diabetes mellitus, n (%) | 3 (8) | 10 (21) | .17 |
| Coronary artery disease, n (%) | 3 (8) | 4 (8) | >.99 |
| Chronic obstructive lung disease, n (%) | 3 (8) | 6 (12) | .79 |
| Computed tomography† | |||
| Consolidation, n (%) | 21 (58) | 25 (60) | >.99 |
| Ground glass opacity, n (%) | 31 (86) | 41 (98) | .14 |
| Bilateral infiltration, n (%) | 33 (92) | 37 (88) | .89 |
| Scores‡ | |||
| qSOFA score, n (%)E1 | 12 (37) | 18 (46) | .62 |
| CURB-65 score ≥ 1, n (%)E2 | 7 (29) | 15 (65) | .029 |
| MuLBSTA score, n (%)E3 | 9 (4-15) | 11 (0-15) | .13 |
| Median lymphocyte count, G/L (range) | 0.99 (0.45-2.5) | 0.8 (0.2-2.84) | .27 |
| Median CRP level, mg/L (range) | 28 (0-315) | 42 (1-369) | .10 |
| Median bilirubin level, mg/dL (range) | 0.5 (0.2-1.9) | 0.5 (0.2-1.2) | .71 |
| Median WBC count, G/L (range) | 5.04 (2.12-308) | 6 (0.15-25.8) | .47 |
| Median LDH level, U/L (range) | 285 (153-1078) | 336 (181-1121) | .18 |
| Median PCT level, ng/mL (range) | 0 (0-5) | 0 (0-2.3) | .32 |
| Median IL-6 level, pg/mL (range) | 27.1 (0-430) | 42.7 (0-272) | .34 |
| Median thrombocyte count, G/L (range) | 161 (0.12-440) | 216 (93-450) | .0084 |
| Median troponin T level, ng/mL (range) | 0 (0-0.032) | 0 (0-0.178) | .016 |
| Median creatinine level, mg/dL (range) | 0.9 (0.4-2.1) | 0.9 (0.5-7.0) | .82 |
| Median D-dimer level, ng/mL (range) | 0.7 (0-2.9) | 0.8 (0-35.2) | .57 |
| Median ferritin level, ng/mL (range) | 626 (46-2153) | 789 (30-3577) | .20 |
q Values represent the Benjamini-Hochberg adjusted P values. Boldface indicates statistical significance.
BMI, Body mass index; LDH, lactate dehydrogenase; PCT, procalcitonin; WBC, white blood cell count.
∗
Respiratory rate, heart rate, and BMI were measured at admission; existing comorbidities were evaluated by patient history at admission.
†
CT-scans and laboratory parameters at admission.
‡
Scores were calculated at admission. CURB-65 score predicts mortality in community-acquired pneumonia; qSOFA score predicts mortality in sepsis; and MuLBSTA score predicts mortality in patients with viral pneumonia.