Table 3.
Maternal and neonatal characteristics detailed for suspected materno-fetal infection with positive neonatal IgM for SARS-CoV2 at birth.
| Zeng H et al. [30] | Dong et al. [31] | ||
|---|---|---|---|
| N° of patient | 1 | 2 | 1 |
| Age of patiente | NS | NS | 29 |
| Gestational age at infection (WG,days) | 3d trimester | 3d trimester | 34 + 2 |
| Gestational age at admission (WG, days) | NS | NS | 35 |
| Term of delivery | NS | NS | 37 + 6 |
| Infection to delivery interval (days) | NS | NS | 25 |
| Maternal clinical characteristics | All 6mothers had mild clinical manifestations. All had cesarean deliveries in their third trimester. | A primiparous woman suspected of being exposed to SARS-CoV-2 developed a temperature of 37.9 °C and nasal congestion, which progressed to respiratory difficulties. A chest CT showed patchy ground-glass opacities in the periphery of both lungs. The RT-PCR on a nasopharyngeal swab was positive. The patient was admitted to RenminHospital and received antiviral, antibiotic, corticosteroid, and oxygen therapies. | |
| Mode of delivery | Caesarian section | Caesarian section | ceasarian section |
| Maternal RT-PCR 2 in nasopharyngeal swab | Positive | Positive | Positive |
| Maternal RT-PCR in feces | NP | NP | NP |
| Maternal RT-PCR in vaginal swab | NP | NP | negative |
| Maternal RT-PCR in breast milk | NP | NP | Negative |
| N° of newborn | 1 | 2 | 1 |
| Preventive mesurement | All had deliveries in negative pressure isolation rooms. All mothers wore masks, and all medical staff wore protective suits and double masks. The infants were isolated from their mothers immediately after delivery | An infant girl was delivered in a negative-pressure isolation room. The mother wore an N95 mask and did not hold the infant. The infant was immediately quarantined in the neonatal intensive care unit. | |
| Neonatal clinical characteristics | All 6 infants had 1-minute Apgar scores of 8 to 9 and 5-minute Apgar scores of 9 to 10. None of the infants presented any symptoms. | 1 | Her birth weight was 3120 g and Apgar scores were 9 at 1 minute and 10 at 5 minutes. The neonate had no symptoms. |
| Neonatal RT-PCR in nasopharyngeal swab | Negative | Negative | Negative |
| Neonatal RT-PCR in amniotic fluid | NP | NP | NP |
| Neonatal RT-PCR in placenta | NA | NA | NP |
| Neonatal RT-PCR in cord blood | Negative | Negative | NP |
| IgM for SARS-CoV-2 in newborn | Positive IgG level of 125.5 AU/mL (reference range < 10) and IgM level of 39.6 AU/mL (reference range < 10) | Positive IgG level of 113.91 AU/mL (reference range < 10) and IgM level of 16.25 AU/mL (reference range < 10) | Positive At 2 hours of age, the SARS-CoV-2 IgG level was 140.32 AU/mL and the IgM level was 45.83 AU/mL. Her IgM (11.75 AU/mL) and IgG (69.94 AU/mL) levels were still elevated on March 7 (reference range < 10), and she was discharged on March 18. |
NP = not performed / NS = Not stated.