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. 2017 Mar 16;15(3):e04691. doi: 10.2903/j.efsa.2017.4691

Figure 2.

Figure 2

Proposed KERs‐based testing strategy established on the AOPs for ‘Parkinsonian Motor Deficits’. Assay 1: measurement of oxidative stress; Assay 2: assessment of mitochondrial function; Assay 3: determination of proteasomal function as a measure of proteostasis; Assay 4: identification of α‐synuclein accumulation; and Assay 5: assessment of dopaminergic cell death