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. 2017 Mar 16;15(3):e04691. doi: 10.2903/j.efsa.2017.4691

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© 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.

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Figure A.6 — Effect of CI (NADH decylubiquinone reductase) inhibition on endogenous cell respiration. Cells were treated with different concentrations of rotenone for 4 h before measuring cell respiration in whole cells and CI activity in isolated mitochondria. Complete CI inhibition was achieved with 100 nM rotenone. The cell respiration was inhibited also in a dose‐dependent manner but showed different inhibition kinetics and a saturation threshold. For comparison, the genetically altered cell line HXC had an approximately 40% CI reduced activity and an approximately 80% residual cell respiration. HXC, human xenomitochondrial cybrids (This research was originally published in the Journal of Biological Chemistry, Barrientos and Moraes, 1999, copyright the American Society for Biochemistry and Molecular Biology)