Figure A.11.

Dose‐ and time‐dependent striatal proteasome activity after MPTP continuously infused up to 28 days measured by relative chymotrypsin‐like, trypsin‐like, and peptidyl‐glutamyl‐peptide hydrolysing (PGPH) proteasome activities in mice. Delayed and prolonged inhibition of proteasome activity after continuous MPTP administration (1, 5 or 30 mg/kg MPTP daily) for the indicated time periods. Asterisks indicate statistically significant differences (p < 0.05) from baseline proteasome activity (single asterisk) or from both baseline proteasome activity and activity after lower MPTP doses (1 and 5 mg/kg, daily, double asterisk; n = 5 mice) (Fornai et al., 2005, fig. 2B, copyright The National Academy of Sciences)