Figure A.18.
Effect of an α‐synuclein deletion on MPTP toxicity. (B) Uptake of [14C]2‐DG in littermate wild‐type and α‐synuclein KO mice that were continuously infused for 7 days with control or MPTP (30 mg/kg daily) solution. Pictures display false‐colour autoradiograms. (C) Proteasome activity in control and α‐synuclein KO mice continuously infused with MPTP (30 mg per kg of body weight daily). Proteasome activities in the substantia nigra are depicted as per cent of control (means ± SEMs) as a function of time after beginning of the infusions (five mice per group). In A and C, asterisks indicate statistically significantly different values (p < 0.05) from controls (Fornai et al., 2005. fig. 5, copyright The National Academy of Sciences)