Figure 4. Effects of melanogenic inhibition on the pigmentation of zebrafish treated with C. islandica extracts.

Effects of melanogenic inhibition on the pigmentation of zebrafish treated from 8 hpf to 56 hpf with C. islandica extract. All images are oriented to have rostral to the right and dorsal at the top. Bright field images of embryos treated with (A) arbutin (10 mM) used as a positive control; untreated zebrafish used as negative control (B); C. islandica chloroform-methanol extract: 5 µg/ml (C); 25 µg/ml (D); 50 µg/ml (E); 65 µg/ml (F). Scale bar: 100 µm.