TABLE 1.
Top 10 most significantly enriched GO categories of the differentially expressed miRNAs.
| GO ID | Term | Annotated | Significant | Expected | KS |
| Biological processes | |||||
| GO:0007411 | Axon guidance | 397 | 377 | 347.57 | 1.9E-12 |
| GO:0071586 | CAAX-box protein processing | 26 | 26 | 22.76 | 7.6E-10 |
| GO:1900246 | Positive regulation of RIG-I signaling pathway | 27 | 27 | 23.64 | 3.7E-09 |
| GO:0045944 | Positive regulation of transcription by RNA polymerase II | 849 | 793 | 743.3 | 6.2E-09 |
| GO:1900245 | Positive regulation of MDA-5 signaling pathway | 26 | 26 | 22.76 | 9E-09 |
| GO:0050691 | Regulation of defense response to virus by host | 55 | 54 | 48.15 | 1.1E-08 |
| GO:0031064 | Negative regulation of histone deacetylation | 25 | 25 | 21.89 | 2.2E-08 |
| GO:0090315 | Negative regulation of protein targeting to membrane | 27 | 26 | 23.64 | 3.8E-08 |
| GO:0090084 | Negative regulation of inclusion body assembly | 12 | 11 | 10.51 | 6.4E-07 |
| GO:0001525 | Angiogenesis | 406 | 386 | 355.45 | 1.00E-06 |
| Molecular functions | |||||
| GO:0030054 | Cell junction | 879 | 831 | 767.72 | 2.30E-08 |
| GO:0005737 | Cytoplasm | 10,110 | 9,044 | 8,830.1 | 5.80E-08 |
| GO:0005667 | Transcription factor complex | 353 | 330 | 308.31 | 3.60E-07 |
| GO:0005634 | Nucleus | 6,542 | 5,808 | 5,713.8 | 4.00E-06 |
| GO:0045202 | Synapse | 559 | 520 | 488.23 | 1.70E-05 |
| GO:0005583 | Fibrillar collagen trimer | 26 | 26 | 22.71 | 3.10E-05 |
| GO:0005604 | Basement membrane | 99 | 95 | 86.47 | 4.60E-05 |
| GO:0005874 | Microtubule | 380 | 355 | 331.89 | 6.30E-05 |
| GO:0072357 | PTW/PP1 phosphatase complex | 13 | 13 | 11.35 | 8.50E-05 |
| GO:0045211 | Postsynaptic membrane | 213 | 199 | 186.03 | 0.00017 |
| Cellular components | |||||
| GO:0043565 | Sequence-specific DNA binding | 746 | 711 | 651.87 | 3.80E-11 |
| GO:0003700 | DNA-binding transcription factor activity | 1,119 | 1,034 | 977.8 | 7.80E-09 |
| GO:0008134 | Transcription factor binding | 536 | 494 | 468.37 | 7.10E-08 |
| GO:0046872 | Metal ion binding | 4,280 | 3,837 | 3,739.9 | 8.60E-08 |
| GO:0044212 | Transcription regulatory region DNA binding | 406 | 396 | 354.77 | 1.60E-06 |
| GO:0003779 | Actin binding | 381 | 368 | 332.92 | 9.00E-06 |
| GO:0005524 | ATP binding | 1,605 | 1,458 | 1,402.5 | 1.70E-05 |
| GO:0005515 | Protein binding | 8,322 | 7456 | 7,271.9 | 1.90E-05 |
| GO:0005543 | Phospholipid binding | 533 | 500 | 465.75 | 2.00E-05 |
| GO:0005488 | Binding | 12,839 | 11,463 | 11,219 | 2.10E-05 |
GO.ID, ID of the GO term; Term, GO function description; Annotated, the number of genes annotated with this function; Significant, the number of differentially expressed miRNA target genes annotated to this function; Expected, the expected number of differentially expressed miRNA target genes annotated to this function; KS statistical significance of the enrichment term (the smaller the KS value, the more significant the enrichment).