TABLE 2.

Ci-miRNA biomarkers related to certain diseases (HMDD database).

	miR-21	miR-146a	miR-126	miR-423	Risk
Lung neoplasms	UP (Liu et al., 2012; Yang et al., 2015; Munagala et al., 2016)				↓
Breast neoplasms	UP (Yan et al., 2008; Schwarzenbach et al., 2012; Kumar et al., 2013; Si et al., 2013; Anfossi et al., 2014; Igglezou et al., 2014; Marino et al., 2014; Matamala et al., 2015; Toraih et al., 2015; Markou et al., 2016; Motawi et al., 2016; Swellam et al., 2018)	UP (Kumar et al., 2013; Markou et al., 2016)			↓
Pancreatic neoplasms	UP (Ali et al., 2010; Abue et al., 2015; Skrha et al., 2015; Goto et al., 2018)				↓
Melanoma		UP (Leidinger et al., 2010; Russo et al., 2016)			↓
Cholangiocarcinoma	UP (Silakit et al., 2017; Liu et al., 2018)				↓
Esophageal neoplasms	UP (Cai et al., 2012; Kurashige et al., 2012; Tanaka et al., 2013)				↓
Colorectal carcinoma	UP (Kanaan et al., 2012; Basati et al., 2014; Wang et al., 2014; Yamada et al., 2015; Zhu et al., 2017)				↓
Coronary artery disease			DOWN (Fichtlscherer et al., 2010; Wang et al., 2017)		↑
Heart failure				UP (Tijsen et al., 2010; Goren et al., 2012; Dickinson et al., 2013)	↑
S group vs. C group	DOWN	DOWN	DOWN	UP

UP and DOWN represent the miRNA being increased or decreased, respectively, in the indicated disease compared with the control. “↓,” “↑,” or “—” indicate the risk that exercise may reduce, increase, or unknown, respectively.