Table 15:
Effect of Vehicle, FGF23, or FGF7 on Rat Fractional Excretion of Pi and Plasma Pi Concentration
| Experimental Group | GFR (mL/minute) | FEP (percent) | Plasma Pi (mM) | |||
|---|---|---|---|---|---|---|
| Dose (number) | C | E | C | E | C | E |
| 1. vehicle; (n = 8) | 3.8 ± 0.5 | 3.9 ± 0.5 | 11.9 ± 2.4 | 15.6 ± 2.6 | 1.6 ± 0.1 | 1.7 ± 0.3 |
| 2. FGF7, 0.1 nmoles/kg/hr; (n = 9) | 3.5 ± 0.4 | 3.0 ± 0.3 | 12.8 ± 1.2 | 27.1 ± 2.6* | 1.7 ± 0.1 | 1.8 ± 0.1 |
| 3. FGF23, 0.1 nmoles/kg/hr; (n = 9) | 3.8 ± 0.2 | 4.2 ± 0.7 | 10.8 ± 1.5 | 25.1 ± 2.6* | 1.8 ± 0.1 | 1.7 ± 0.1 |
| 4. FGF7, 0.01 nmoles/kg/hr; (n = 6) | 3.6 ± 0.4 | 3.4 ± 0.5 | 10.5 ± 1.1 | 21.1 ± 3.5* | 1.7 ± 0.1 | 1.8 ± 0.1 |
| 5. FGF23, 0.01 nmoles/kg/hr; (n = 8) | 4.0 ± 0.5 | 3.4 ± 0.4 | 8.3 ± 1.4 | 17.7 ± 1.3* | 1.7 ± 0.1 | 1.8 ± 0.1 |
C = control clearance period, E = experimental clearance period. GFR = Glomerular filtration rate; FEP = fractional excretion of phosphate; Pi = plasma Pi concentration;
*
= statistically significant P < 0.05. Data are expressed as mean ± standard error of mean.