Table 2.

The carcinogenic effects of DMH in different animal species and strains and their target organs

S.No	Dose/route	No. of injections	Total duration of the experiment (weeks)	Affected organs	Tumor arised	Metastasis	Strain	References
1.	10 mg/kg b.w./s.c.		24	Colon	Large and small intestines		Male Wistar rats	[168]
2.	20 mg/kg b.w./s.c.		24	Colon, liver, small intestine	Large and small intestines	Liver	Male Wistar rats	[168]
3.	35 mg/kg b.w/Oral		78	Small intestine, Zymbal gland			Male Fischer rats	[169]
4.	30 mg/kg b.w./s.c.		20	Colon	Colon		Male Wistar	[170]
5.	30 mg/kg b.w./i.p.	12	24	Small intestine. Colon	Colon	Small intestine	Male Swiss mice	[171]
6.	40 mg/kg b.w./s.c.	4	5	Colon			Male Wistar rats	[165]
7.	30 mg/kg b.w./s.c.	30	30	Colon	Colon		Male Wistar rats	[164]
8.	30 mg/kg b.w./s.c.	16	16	Colon	Colon		Male Wistar rats	[172]
9.	75 mg/kg b.w./s.c.	1	24 hours	Colon			Male F344 rats	[173]
10.	21 mg/kg b.w./s.c.	12	28	Colon			C57 black male mice	[174]
11	21 mg/kg b.w.	15	26	Colon	Colon	Duodenum, jejunum	Female LIO rats	[175]
12.	40 mg/kg b.w./s.c.	4	4	Colon			Male Wistar rats	[176]
13.	40 mg/kg b.w./i.p.	10	10	Colon	Colon		Male Wistar rats	[177]
14.	40 mg/kg b.w./s.c.	8	8	Colon	Colon		Male F344 rats	[178]
15.	40 mg/kg b.w./s.c.	2	2	Colon	Colon		Male Wistar rats	[179]
16.	200 mg/kg b.w.	1	2 days	Liver	Not measured		Fischer 344 rats	[180]
17.	80 mg/kg b.w./i.p.	1	8 hours	Colon			Male BDF1 mice	[181]
18.	15 mg/kg b.w./s.c.	20	52	Colon	Colon		Male F344 rats	[182]
19.	50 mg/kg b.w./s.c.	10	35	Colon, liver, small intestine	Colon	Caecum, small Intestine, liver, abdomen	Male Wistar rats	[183]
20.	30 mg/kg b.w./s.c.	10	26	Colon	Colon		Male F344 rats	[184]
21.	25 mg/kg b.w./s.c.	1	7 days	Liver			Male Wistar rats	[185]
22.	125 mg/kg b.w./i.p.	1	14 days	Colon			Male Wistar rats	[186]
23.	20 mg/kg. b.w./s.c.	15	30	Colon	Colon		Male Wistar rats	[163]
24	20 mg/kg. b.w./s.c.	8	31	Colon	Colon		F344 rats	[187]
25.	20 mg/kg. b.w./s.c.	15	30	Colon	Colon	Caecum	Male Wistar rats	[62]