Table 3.
Patient Characteristics at Enrollment and during Follow-up, by Interstitial Lung Disease Event Type
| ILD Events |
No Event (n = 104) | ||
|---|---|---|---|
| Developed Clinical ILD or Extensive ILA (n = 12) | ILA Progressed on HRCT 2 (n = 13) | ||
| Characteristics at enrollment | |||
| Age, yr, mean (SD) | 59.7 (12.2) | 53.4 (9.6) | 51.6 (7.3) |
| Sex, F, n (%) | 6 (50) | 4 (31) | 69 (66) |
| Ever smoker, n (%) | 5 (42) | 6 (46) | 26 (25) |
| MUC5B GT or TT, n (%) | 5 (42) | 5 (39) | 30 (29) |
| TRF length, kb, mean (SD) | 6.17 (1.07) | 6.26 (0.96) | 6.47 (1.04) |
| HRCT findings | |||
| ILA category, n (%) | |||
| None | 0 (0) | 6 (46.2) | 93 (89) |
| Early/mild | 12 (100) | 7 (53.9) | 11 (11) |
| Honeycombing, n (%) | 3 (25) | 0 (0) | 0 (0) |
| Ground-glass opacities, n (%) | 4 (33) | 1 (7.7) | 5 (5) |
| Intralobular reticular opacities, n (%) | 12 (100) | 5 (39) | 7 (7) |
| Irregular septal thickening, n (%) | 10 (83) | 4 (31) | 4 (4) |
| Traction bronchiectasis, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Traction bronchiolectasis, n (%) | 1 (8) | 0 (0) | 1 (1) |
| Bilateral interstitial features, n (%) | 9 (75) | 3 (23) | 4 (4) |
| Visual ILA score, median (Q1–Q3) | 5.0 (3.5–12.0) | 0 (0–2) | 0 (0–0) |
| DTA score, median (Q1–Q3) | 3.8 (1.0–9.3) (n = 11) | 1.0 (0.7–1.5) (n = 13) | 0.8 (0.4–1.4) (n = 100) |
| Characteristics during longitudinal follow-up | |||
| Second HRCT findings | n = 6 | n = 13 | n = 67 |
| Inter-HRCT interval, yr, median (Q1–Q3) | 5.7 (3.8–6.2) | 5.3 (5.0–5.7) | 5.0 (3.6–6.2) |
| ILA category, n (%) | |||
| None | 0 (0) | 1 (7.7) | 65 (97.0) |
| Early/mild ILA | 2 (33.3) | 12 (92.3) | 2 (3.0) |
| Extensive ILA | 4 (66.7) | 0 (0) | 0 (0) |
| Honeycombing, n (%) | 2 (33) | 1 (7.7) | 0 (0) |
| Bilateral interstitial features, n (%) | 6 (100) | 8 (61.5) | 0 (0) |
| Visual ILA score, median (Q1–Q3) | 24.5 (15.0–27.0) | 6.0 (2.0–13.0) | 0 (0–0) |
| DTA score, median (Q1–Q3) | n/a (n = 1) | 2.2 (0.7–4.1) (n = 12) | 0.6 (0.4–1.3) (n = 62) |
| Yearly change in dyspnea score, mean (SD) | 0.2 (0.5) (n = 10) | 0.04 (0.1) | −0.04 (0.2) (n = 89) |
| Yearly change in visual ILA score, mean (SD) | 3.7 (1.7) (n = 6) | 0.8 (0.6) | −0.05 (0.3) (n = 67) |
| Yearly change in DTA score, mean (SD) | n/a (n = 1) | 0.36 (0.55) (n = 12) | −0.09 (0.62) (n = 62) |
Definition of abbreviations: DTA = data-driven textural analysis; HRCT = high-resolution computed tomography; ILA = interstitial lung abnormalities; ILD = interstitial lung disease; n/a = not applicable (mean yearly change not calculated for one subject with available data); Q1–Q3 = interquartile range; TRF = telomere restriction fragment.
n = 129 subjects, except where noted. Continuous values are given as mean (SD) or median (interquartile range).