Table 5:

Multivariable-adjusted risk of mortality subtypes by total flavonoid and flavonoid class, comparing participants in the lowest quintile of flavonoid intake (referent group) to those in the highest quintile.¹

	Cancer mortality3	CVD mortality4	Other-cause5
	Quintile 5	Quintile 5	Quintile 5
Total flavonoid intake
Age-adjusted	0.80 (0.64–0.98)	0.66 (0.43–1.02)	0.86 (0.71–1.05)
Multivariable-adjusted2	0.84 (0.67–1.04)	0.83 (0.53–1.29)	1.03 (0.84–1.26)
Flavonol intake
Age-adjusted	0.98 (0.80–1.20)	0.76 (0.50–1.16)	1.08 (0.88–1.31)
Multivariable-adjusted2	0.99 (0.80–1.24)	0.91 (0.58–1.41)	1.22 (0.99–1.51)
Flavan-3-ol intake
Age-adjusted	0.84 (0.68–1.04)	0.64 (0.42–0.98)	0.85 (0.70–1.04)
Multivariable-adjusted2	0.87 (0.70–1.08)	0.75 (0.49–1.16)	0.96 (0.78–1.17)
Proanthcyanin intake
Age-adjusted	0.86 (0.70–1.06)	0.64 (0.41–0.99)	0.83 (0.68–1.00)
Multivariable-adjusted2	0.90 (0.72–1.11)	0.77 (0.49–1.20)	0.97 (0.79–1.18)
Flavone intake
Age-adjusted	0.89 (0.72–1.10)	0.74 (0.48–1.16)	0.91 (0.75–1.12)
Multivariable-adjusted2	1.00 (0.80–1.06)	1.15 (0.72–1.83)	1.22 (0.99–1.51)
Flavanone intake
Age-adjusted	0.91 (0.73–1.13)	0.81 (0.51–1.28)	0.95 (0.77–1.18)
Multivariable-adjusted2	1.03 (0.83–1.29)	1.10 (0.69–1.76)	1.21 (0.97–1.50)
Anthocyanin intake
Age-adjusted	0.74 (0.59–0.91)	0.48 (0.30–0.78)	0.74 (0.61–0.90)
Multivariable-adjusted2	0.77 (0.61–0.98)	0.85 (0.50–1.43)	1.10 (0.88–1.37)

¹Results are HR (95% CI) and n(%) where appropriate. n = 93,145).

²Multivariable adjusted model includes: age, body mass index, smoking status, menopausal status, family history of diabetes, cancer and myocardial infarction, multivitamin supplement use, Aspirin use, race, type 2 diabetes, hypercholesterolemia, hypertension, physical activity, caloric intake, alcohol consumption and the Alternative Health Eating Index (minus alcohol) score.

³Total number of cancer mortalities: 887.

⁴Total number of cardiovascular disease (CVD) mortalities: 189.

⁵Total number of mortalities from other causes: 818