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A detailed comparison of PLD1 and PLD2 structure. PLD1 and PLD2 display 51% sequence homology and share a conserved structure with 4 conserved PLD regions (CR), of which CRII and IV contain the catalytic sequence HKD. They both contain PX- and PH-domains and a PIP2 binding motif. PLD1 contains a loop sequence between CRII and CRIII absent in PLD2. Known and potential region-specific functions are indicated.
