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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Prog Lipid Res. 2019 Dec 9;78:101018. doi: 10.1016/j.plipres.2019.101018

Table 1.

Functions and disease relevance of mammalian PLD1.

Cancer (Melanoma), metastasis, angiogenesis. [43,224,481]
Pathological hemostasis (e.g. strokes and pulmonary embolisms, autophagy, proteinopathies). [42,185]
Brain development. [187]
 Behavioral stimulation response, cognitive function, social recognition.
Receptor internalization. [353]
Secretion/ exocytosis. [373–377,381]
Actin Stress fiber formation, adhesion/ cell spreading. [391,392,394]
ROS production. [184]
Lipid droplet formation. [439,440]
Integrin activation. [42]
Diabetes. [558,560]

A large number of studies have identified important roles for PLD1 in cellular and physiological processes as diverse as endocytosis, lipid droplet formation, cytoskeletal regulation, cognitive function and social recognition. PLD1 has also been implicated in numerous diseases including diabetes, strokes and cancer. Numbers in parentheses refer to reference number in manuscript bibliography.