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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Prog Lipid Res. 2019 Dec 9;78:101018. doi: 10.1016/j.plipres.2019.101018

Table 2.

Functions and disease relevance of mammalian PLD2.

Cancers including renal, breast, colorectal, bladder and lung. Tumor transformation, tumor metastasis and invasion. Angiogenesis. [458,464,482,489,491,494]
Alzheimer’s disease (AD), brain development, behavioral stimulation response, cognitive function, social and object recognition. [39,187,188]
Receptor internalization, recycling and trafficking. [41,97,168,334,339–341,353,354,364]
Golgi/ TGN clathrin-coated vesicle formation, Golgi, and lysosome structural maintenance. [8,10,179,384]
Adhesion. [392,394]
Blood pressure regulation, thrombotic disease. [44,168,196,452]

A large number of studies have indicated a diverse range of important cellular and physiological PLD2 functions including receptor internalization, Golgi function, cellular adhesion, behavioral stimulation response and blood pressure regulation. PLD2 has also been linked to a number of human diseases including Alzheimer’s disease and cancer. Numbers in parentheses refer to reference number in manuscript bibliography.