Table 1.

Summary statistics for demographic, TICS, APOE genetics and biomarkers for the sample.

Measurement	Full cohort	Impaired	Unimpaired	P value for difference between affected and Unaffected
n	6545	355	6190
Age, mean (SD), y	72.22 (7.48)	78.85 (7.46)	71.84 (7.30)	< 0.0001
% Female	57.51	57.69	54.37	ns
Education	12.57 (3.05)	11.32 (3.78)	12.64 (2.99)	< 0.0001
CRP mean (SD)	2.12 (3.75)	1.96 (3.72)	2.13 (3.75)	ns
HDL mean (SD)	55.36 (15.37)	53.38 (13.70)	55.48 (15.46)	0.033
LDL mean (SD)	139.06 (42.42)	138.15 (43.37)	139.11 (42.37)	ns
TC mean (SD)	191.55 (44.36)	189.49 (46.50)	191.67 (44.23)	ns
APOE genotypes
APOE ε2/ε2	0.98%	0.28%	1.02%	ns
APOE ε2/ε3	16.24%	14.93%	16.32%	ns
APOE ε2/ε4	2.31%	4.23%	2.20%	0.013
APOE ε3/ε3	61.57%	51.55%	62.15%	P < 0.0001
APOE ε3/ε4	17.82%	24.79%	17.42%	0.0004
APOE ε4/ε4	1.08%	4.23%	0.90%	P < 0.0001
APOE ε4 carrier	21.21%	33.24%	20.52%	P < 0.0001