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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Neurobiol Aging. 2019 Mar 6;80:173–186. doi: 10.1016/j.neurobiolaging.2018.10.028

Table 2.

Loci reaching statistical significance at FDR ≤0.05 for association with cognitive impairment conditional on association for the plasma lipids and CRP phenotypes.

Biomarker SNP Chr Position Nearest Gene Minor allele MAF Conditional FDR Cognitive Impairment P Value Cognitive Impairment OR (95% CI) Biomarker Beta (95% CI)
CRP rs73058377 7 9,080,297 AC009500.2 T 0.40 1.03E-02 7.28E-05 1.31 (1.12 – 1.60) −0.26 (−0.39 – −0.13)
CRP rs1541411 7 9,081,364 AC009500.2 A 0.46 5.78E-02 4.38E-04 1.25 (1.08 – 1.49) −0.24 (−0.37 – −0.11)
CRP rs11561890 7 9,086,743 AC009500.2 G 0.42 9.54E-02 2.90E-04 1.28 (1.09 – 1.55) −0.23 (−0.36 – −0.10)
CRP rs118110581 19 31,450,347 CTC-400I9.3 C 0.06 7.92E-02 1.13E-04 1.63 (1.16 – 2.74) −0.44 (−0.71 – −0.17)
CRP rs12972156 19 45,387,459 PVRL2 C 0.13 1.81E-06 1.83E-09 1.72 (1.32 – 2.47) 0.35 (0.16 – 0.54)
CRP rs12972970 19 45,387,596 PVRL2 G 0.13 1.57E-06 1.85E-09 1.72 (1.32 – 2.46) 0.35 (0.16 – 0.54)
CRP rs34342646 19 45,388,130 PVRL2 G 0.13 1.49E-06 2.02E-09 1.71 (1.32 – 2.45) 0.35 (0.16 – 0.54)
CRP rs283812 19 45,388,568 PVRL2 T 0.21 3.22E-04 1.02E-07 1.50 (1.23 – 1.94) 0.24 (0.07 – 0.41)
CRP rs283815 19 45,390,333 PVRL2 A 0.24 8.92E-04 9.69E-07 1.41 (1.18 – 1.75) 0.25 (0.09 – 0.40)
CRP rs6857 19 45,392,254 PVRL2 C 0.14 7.42E-09 3.75E-12 1.79 (1.38 – 2.53) 0.48 (0.30 – 0.65)
CRP rs71352238 19 45,394,336 TOMM40 T 0.12 4.32E-06 1.97E-08 1.65 (1.28 – 2.32) 0.38 (0.20 – 0.57)
CRP rs184017 19 45,394,969 TOMM40 T 0.24 1.64E-04 1.59E-07 1.45 (1.21 – 1.82) 0.24 (0.08 – 0.40)
CRP rs2075650 19 45,395,619 TOMM40 A 0.13 1.23E-05 6.86E-08 1.57 (1.25 – 2.11) 0.37 (0.18 – 0.56)
CRP rs157581 19 45,395,714 TOMM40 T 0.24 9.33E-04 1.17E-06 1.41 (1.18 – 1.75) 0.24 (0.08 – 0.40)
CRP rs34404554 19 45,395,909 TOMM40 C 0.13 2.92E-06 1.18E-08 1.62 (1.28 – 2.21) 0.37 (0.18 – 0.56)
CRP rs11556505 19 45,396,144 TOMM40 C 0.13 9.33E-06 4.72E-08 1.58 (1.26 – 2.14) 0.37 (0.18 – 0.56)
CRP rs157582 19 45,396,219 TOMM40 C 0.24 8.85E-04 1.06E-06 1.41 (1.18 – 1.75) 0.24 (0.08 – 0.40)
CRP rs59007384 19 45,396,665 TOMM40 G 0.22 5.58E-04 5.75E-07 1.43 (1.19 – 1.80) 0.26 (0.10 – 0.42)
CRP rs769449 19 45,410,002 APOE G 0.10 1.74E-08 3.51E-11 1.87 (1.39 – 2.85) 0.42 (0.22 – 0.63)
CRP rs429358 19 45,411,941 APOE T 0.14 2.16E-08 5.47E-11 1.69 (1.34 – 2.31) 0.50 (0.31 – 0.69)
CRP rs10414043 19 45,415,713 APOE G 0.12 1.62E-04 9.84E-07 1.53 (1.21 – 2.07) 0.42 (0.22 – 0.63)
CRP rs7256200 19 45,415,935 APOE G 0.12 2.19E-04 1.44E-06 1.52 (1.21 – 2.06) 0.42 (0.22 – 0.63)
CRP rs73052335 19 45,420,082 APOC1 A 0.10 5.92E-09 8.97E-12 1.94 (1.42 – 3.06) 0.41 (0.20 – 0.62)
CRP rs12721046 19 45,421,254 APOC1 G 0.12 2.07E-06 7.10E-10 1.78 (1.34 – 2.63) 0.30 (0.10 – 0.50)
CRP rs12721051 19 45,422,160 APOC1 C 0.15 7.07E-09 7.15E-12 1.79 (1.38 – 2.54) 0.38 (0.19 – 0.56)
CRP rs56131196 19 45,422,846 APOC1 G 0.16 2.62E-06 7.94E-09 1.59 (1.27 – 2.12) 0.38 (0.19 – 0.56)
CRP rs4420638 19 45,422,946 APOC1 A 0.16 2.56E-06 9.06E-09 1.59 (1.27 – 2.11) 0.38 (0.19 – 0.56)
CRP rs111789331 19 45,427,125 APOC1 T 0.12 1.20E-05 6.87E-09 1.75 (1.32 – 2.62) 0.34 (0.13 – 0.54)
CRP rs66626994 19 45,428,234 APOC1 G 0.13 2.39E-03 8.92E-07 1.59 (1.23 – 2.24) 0.31 (0.10 – 0.52)
LDL rs11620068 13 46,300,824 SPERT A 0.14 4.71E-02 1.04E-05 1.45 (1.17 – 1.90) −3.39 (−5.81 – −0.98)
LDL rs6857 19 45,392,254 PVRL2 C 0.14 2.08E-08 3.75E-12 1.79 (1.38 – 2.53) −4.02 (−6.41 – −1.63)
LDL rs769449 19 45,410,002 APOE G 0.10 1.99E-07 3.51E-11 1.87 (1.39 – 2.85) −4.31 (−7.07 – −1.55)
LDL rs429358 19 45,411,941 APOE T 0.14 2.33E-07 5.47E-11 1.69 (1.34 – 2.31) −4.10 (−6.64 – −1.57)
LDL rs10414043 19 45,415,713 APOE G 0.12 2.40E-03 9.84E-07 1.53 (1.21 – 2.07) −4.57 (−7.33 – −1.82)
LDL rs7256200 19 45,415,935 APOE G 0.12 3.06E-03 1.44E-06 1.52 (1.21 – 2.06) −4.56 (−7.32 – −1.80)
LDL rs73052335 19 45,420,082 APOC1 A 0.10 1.62E-07 8.97E-12 1.94 (1.42 – 3.06) −4.25 (−7.09 – −1.42)
LDL rs12721046 19 45,421,254 APOC1 G 0.12 6.41E-06 7.10E-10 1.78 (1.34 – 2.63) −3.75 (−6.40 – −1.10)
LDL rs12721051 19 45,422,160 APOC1 C 0.15 6.09E-08 7.15E-12 1.79 (1.38 – 2.54) −3.86 (−6.34 – −1.39)
LDL rs56131196 19 45,422,846 APOC1 G 0.16 2.71E-05 7.94E-09 1.59 (1.27 – 2.12) −3.98 (−6.45 – −1.51)
LDL rs4420638 19 45,422,946 APOC1 A 0.16 2.57E-05 9.06E-09 1.59 (1.27 – 2.11) −3.98 (−6.45 – −1.51)
LDL rs66626994 19 45,428,234 APOC1 G 0.13 5.37E-03 8.92E-07 1.59 (1.23 – 2.24) −3.78 (−6.58 – −0.98)
TC rs12972156 19 45,387,459 PVRL2 C 0.13 1.77E-05 1.83E-09 1.72 (1.32 – 2.47) −3.22 (−5.62 – −0.83)
TC rs12972156 19 45,387,459 CTB-129P6.4 C 0.13 1.77E-05 1.83E-09 1.72 (1.32 – 2.47) −3.22 (−5.62 – −0.83)
TC rs12972970 19 45,387,596 PVRL2 G 0.13 1.53E-05 1.85E-09 1.72 (1.32 – 2.46) −3.22 (−5.62 – −0.83)
TC rs12972970 19 45,387,596 CTB-129P6.4 G 0.13 1.53E-05 1.85E-09 1.72 (1.32 – 2.46) −3.22 (−5.62 – −0.83)
TC rs34342646 19 45,388,130 PVRL2 G 0.13 1.46E-05 2.02E-09 1.71 (1.32 – 2.45) −3.22 (−5.60 – −0.83)
TC rs34342646 19 45,388,130 CTB-129P6.4 G 0.13 1.46E-05 2.02E-09 1.71 (1.32 – 2.45) −3.22 (−5.60 – −0.83)
TC rs6857 19 45,392,254 PVRL2 C 0.14 2.34E-08 3.75E-12 1.79 (1.38 – 2.53) −3.83 (−6.08 – −1.58)
TC rs6857 19 45,392,254 CTB-129P6.4 C 0.14 2.34E-08 3.75E-12 1.79 (1.38 – 2.53) −3.83 (−6.08 – −1.58)
TC rs34404554 19 45,395,909 TOMM40 C 0.13 6.21E-05 1.18E-08 1.62 (1.28 – 2.21) −3.19 (−5.55 – −0.83)
TC rs11556505 19 45,396,144 TOMM40 C 0.13 2.28E-04 4.72E-08 1.58 (1.26 – 2.14) −3.18 (−5.54 – −0.82)
TC rs769449 19 45,410,002 APOE G 0.10 5.08E-07 3.51E-11 1.87 (1.39 – 2.85) −4.17 (−6.76 – −1.59)
TC rs429358 19 45,411,941 APOE T 0.14 6.33E-07 5.47E-11 1.69 (1.34 – 2.31) −3.87 (−6.24 – −1.49)
TC rs10414043 19 45,415,713 APOE G 0.12 3.06E-03 9.84E-07 1.53 (1.21 – 2.07) −4.62 (−7.20 – −2.04)
TC rs7256200 19 45,415,935 APOE G 0.12 2.98E-03 1.44E-06 1.52 (1.21 – 2.06) −4.60 (−7.18 – −2.02)
TC rs73052335 19 45,420,082 APOC1 A 0.10 1.73E-07 8.97E-12 1.94 (1.42 – 3.06) −3.84 (−6.48 – −1.19)
TC rs12721051 19 45,422,160 APOC1 C 0.15 2.07E-07 7.15E-12 1.79 (1.38 – 2.54) −3.07 (−5.39 – −0.76)
TC rs56131196 19 45,422,846 APOC1 G 0.16 5.11E-05 7.94E-09 1.59 (1.27 – 2.12) −3.17 (−5.48 – −0.86)
TC rs4420638 19 45,422,946 APOC1 A 0.16 5.24E-05 9.06E-09 1.59 (1.27 – 2.11) −3.17 (−5.48 – −0.86)