There is no difference in the development of SIRS between patients with or without SC by 24 hrs of stroke onset. After stratifying by age however, there is an increase in SIRS in patients without SC in those >75 years of age. Models are adjusted for: age, sex, race-ethnicity, infection, beta blocker usage, NIHSS at admission, prior stroke, and the interaction terms SC x Age>75 and SC x African American race.