There is no difference in leukocytosis in patients with and without SC, however on closer evaluation there are changes in the composition of the total white blood cell (WBC) count. There in multivariate modeling, there is higher lymphocyte percentage in patients with SC and a lower neutrophil percentage in patients without SC. Models are adjusted for: age, sex, race-ethnicity, infection, beta blocker usage, NIHSS at admission, prior stroke, and the interaction terms SC x Age>75 and SC x African American race.