Table 1.
Symptom prevalence and severity at baselinea, 1 month after last chemotherapy, and 1 year after baseline
| Symptoms | Baselinea (n=202-204) | 1 month after last CTX (n=180-182) | 1 year after baseline (n=173) | P | |||
|---|---|---|---|---|---|---|---|
| Prevalence (%) | Severity, mean (SD) | Prevalence (%) | Severity, mean (SD) | Prevalence (%) | Severity, mean (SD) | ||
| Nauseab | 22.1 | 0.32 (0.68) | 13.7 | 0.16 (0.44) | 11.6 | 0.16 (0.50) | 0.025 |
| Painb | 84.8 | 1.28 (0.79) | 61.0 | 0.88 (0.86) | 60.1 | 0.88 (0.88) | <0.01 |
| Appetiteb | 41.2 | 0.45 (0.62) | 28.6 | 0.34 (0.62) | 8.7 | 0.12 (0.47) | <0.01 |
| Sleep disturbanceb | 76.0 | 1.25 (0.91) | 64.8 | 0.90 (0.89) | 62.4 | 0.90 (0.86) | <0.01 |
| Fatigueb | 89.2 | 1.21 (0.64) | 94.5 | 1.32 (0.64) | 86.1 | 1.20 (0.68) | 0.02 |
| Bowel patternb | 37.7 | 0.46 (0.70) | 29.2 | 0.37 (0.64) | 25.4 | 0.31 (0.58) | 0.03 |
| Concentrationb | 54.7 | 0.66 (0.69) | 59.9 | 0.74 (0.71) | 42.8 | 0.53 (0.68) | <0.01 |
| Appearanceb | 24.5 | 0.26 (0.49) | 33.5 | 0.42 (0.70) | 13.3 | 0.14 (0.40) | <0.01 |
| Anxietyc | 38.3 | 6.58 (3.87) | 22.4 | 4.62 (3.75) | 23.2 | 4.69 (3.61) | <0.01 |
| Depressionc | 10.9 | 3.25 (3.00) | 13.5 | 3.99 (3.28) | 9.8 | 2.52 (2.71) | <0.01 |
aBaseline defined as prior to starting CTX, bScores range from 0 (most positive result) to 4 (most negative result), cScores range from 0 (least severe) to 21 (most severe). Bonferroni-adjusted P value reflects changes over time. CTX: Chemotherapy